About: Forkhead Box Protein O4     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Forkhead Box Protein O4
equivalentClass
OMIM_Number
  • 300033
Semantic_Type
  • Amino Acid, Peptide, or Protein
Preferred_Name
  • Forkhead Box Protein O4
UMLS_CUI
  • C1333634
Legacy_Concept_Name
  • Forkhead_Box_Protein-O4_Protein
FULL_SYN
  • Forkhead Box Protein O4PTNCI
  • AFXSYNCI
  • AFX1SYNCI
  • FOXO4SYNCI
  • MLLT7SYNCI
  • Trithorax Homolog 7SYNCI
  • Fork Head Domain Transcription Factor AFX1SYNCI
Swiss_Prot
  • P98177
DEFINITION
  • Forkhead box protein O4 (505 aa, ~54 kDa) is encoded by the human FOXO4 gene. This protein plays a role in cell cycle arrest, transcriptional regulation, embryonic development and insulin signaling.NCI
DesignNote
  • Forkhead Box Protein O4 is highly similar to forkhead transcription factor FKHR protein within its single forkhead domain and contains serine- and proline-rich regions like ENL protein. AFX-like proteins appear involved in cell cycle regulation. MLLT7 appears to block cell cycle progression at G1, independent of Rb but dependent on p27(KIP1). MLLT7 transcriptionally activates p27(KIP1). MLLT7 may also play a role in the insulin signaling pathway. Acute leukemia chromosomal translocation t(X;11)(q13;q23) involves MLLT7 fused to MLL/HRX that encodes a chimeric rogue activator protein.
code
  • C33948
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