About: DNA Replication Licensing Factor MCM7     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • DNA Replication Licensing Factor MCM7
equivalentClass
OMIM_Number
  • 600592
Semantic_Type
  • Amino Acid, Peptide, or Protein
Preferred_Name
  • DNA Replication Licensing Factor MCM7
UMLS_CUI
  • C1333241
Legacy_Concept_Name
  • DNA_Replication_Licensing_Factor-MCM7
FULL_SYN
  • CDC47 HomologSYNCI
  • Minichromosome Maintenance Protein 7SYNCI
  • DNA Replication Licensing Factor MCM7PTNCI
  • CDC47SYNCI
  • p85MCMSYNCI
  • P1CDC47SYNCI
  • PNAS-146SYNCI
  • P1.1-MCM3SYNCI
Swiss_Prot
  • P33993
DEFINITION
  • DNA replication licensing factor MCM7 (8719 aa, ~81 kDa) is encoded by the human MCM7 gene. This protein plays a role in the synthesis of a single copy of a genome before mitosis.NCI
DesignNote
  • A stable MCM2/4/6/7 complex possesses DNA helicase activity and may act as a DNA unwinding enzyme. CDC45 binds to MCM7 and DNA polymerase alpha p70 subunit in the final sequential step of active initiation complex assembly and recruits DNA polymerase alpha to origins of replication. Nonenzymatic p70 forms a tight complex with the catalytic DNA polymerase alpha p180 subunit. The hexameric MCM2-7 complex is a key component of the pre-replication complex and may be involved in formation of replication forks and in recruitment of replication factors. CDK4 associates with MCM7 and MCM7 binds RB1/RB.
code
  • C33912
is sameAs of
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