About: Busulfan

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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	Class
rdfs:label	Busulfan
rdfs:subClassOf	Alkanesulfonates
Concept_In_Subset	FDA Established Names and Unique Ingredient Identifier Codes Terminology
Semantic_Type	Organic Chemical Pharmacologic Substance
Preferred_Name	Busulfan
NSC_Code	750
UMLS_CUI	C0700015
CAS_Registry	55-98-1
Accepted_Therapeutic_Use_For	Bone marrow disorders; chronic myelogenous leukemia; palliative; neoadjuvant to allogeneic hematopoietic progenitor cell transplantation; neoplastic meningitis; primary brain malignancies
In_Clinical_Trial_For	Ewings sarcoma; lymphoma; multiple myeloma; myelodysplastic syndrome; myeloid leukemia; acute and chronic; neuroblastoma
FDA_UNII_Code	G1LN9045DK
Contributing_Source	FDA
ALT_DEFINITION	An anticancer drug that belongs to the family of drugs called alkylating agents.NCI-GLOSS
PDQ_Open_Trial_Search_ID	41947
PDQ_Closed_Trial_Search_ID	41947
Chemical_Formula	C6H14O6S2
Legacy_Concept_Name	Busulfan
CHEBI_ID	CHEBI:28901
FULL_SYN	GlyzophrolSYNCI MyeloleukonSYDTPNSC0000750 MyeloleukonSYNCI GT 41SYDTPNSC0000750 CB 2041SYDTPNSC0000750 BUSABNCI Tetramethylene Bis(methanesulfonate)SYNCI MyleranSYDTPNSC0000750 BUSULFANPTFDAG1LN9045DK Methanesulfonic acid, tetramethylene esterSYDTPNSC0000750 GT-41CNNCI MisulbanSYDTPNSC0000750 BusulfanSYDTPNSC0000750 MyelosanSYDTPNSC0000750 Tetramethylene bis[methanesulfonate]SYDTPNSC0000750 CB-2041CNNCI MyleranBRNCI MitosanBRNCI BusulphanSYDTPNSC0000750 MylecytanSYDTPNSC0000750 WR-19508CNNCI 1,4-Bitanediol Dimethanesulfonate EstersSNNCI busulfanPTNCI-GLOSSCDR0000045410 MielucinFBNCI MisulbanFBNCI BusulfanPTNCI MisulfanSYNCI BusulfexBRNCI MyelosanSYNCI 1,4-Bis(methanesulfonoxy)butaneSNNCI 1,4-Di(methylsulfonyloxy)butaneSNNCI JoacamineSYNCI BusulphanSYNCI BussulfamSYNCI MylecytanSYNCI MyeleukonSYNCI Methanesulfonic Acid Tetramethylene EsterSYNCI 1, 4-Bis[methanesulfonoxy]butaneSYDTPNSC0000750 1,4-Butanediol DimethylsulfonateSNNCI 1,4-Di(methanesulfonyloxy)butaneSNNCI SulfabutinSYNCI BusulfanumSYNCI
DEFINITION	A synthetic derivative of dimethane-sulfonate with antineoplastic and cytotoxic properties. Although its mechanism of action is not fully understood, busulfan appears to act through the alkylation of DNA. Following systemic absorption of busulfan, carbonium ions are formed, resulting in DNA alkylation and DNA breaks and inhibition of DNA replication and RNA transcription. (NCI04)NCI
code	C321
sameAs	Busulfan
http://linked.open...y/mesh/hasConcept	http://linked.opendata.cz/resource/mesh/concept/M0003081
is someValuesFrom of	nodeID://b645250 nodeID://b646278 nodeID://b646280 nodeID://b646283 nodeID://b651880 nodeID://b651884 nodeID://b651887 nodeID://b651888 nodeID://b651891 nodeID://b651896 nodeID://b651900 nodeID://b651902 nodeID://b651907 nodeID://b651908 nodeID://b651912 nodeID://b651915 nodeID://b651917 nodeID://b651921 nodeID://b651925 nodeID://b651926 nodeID://b651929 nodeID://b651930 nodeID://b651932 nodeID://b651935 nodeID://b651937 nodeID://b651940 nodeID://b651943 nodeID://b651944
is sameAs of	Busulfan

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