About: Chronic Myelogenous Leukemia, BCR-ABL1 Positive

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About: Chronic Myelogenous Leukemia, BCR-ABL1 Positive Goto Sponge NotDistinct Permalink

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Attributes	Values
rdf:type	Class
rdfs:label	Chronic Myelogenous Leukemia, BCR-ABL1 Positive
equivalentClass	nodeID://b631387
Semantic_Type	Neoplastic Process
Preferred_Name	Chronic Myelogenous Leukemia, BCR-ABL1 Positive
UMLS_CUI	C0023473
ALT_DEFINITION	A slowly progressing disease in which too many white blood cells are made in the bone marrow.NCI-GLOSS
ICD-O-3_Code	9863/3 9875/3
Neoplastic_Status	Malignant
Legacy_Concept_Name	Chronic_Myelogenous_Leukemia
FULL_SYN	CMLPTNCI-GLOSSCDR0000044382 chronic myeloid leukemiaPTNCI-GLOSSCDR0000046755 CML - Chronic Myelogenous LeukemiaSYNCI Chronic Myelogenous Leukemia, BCR-ABL1 PositiveSYNCITCGA Chronic Myeloid LeukemiaSYNCI BCR-ABL Positive Chronic Myelogenous LeukemiaSYNCI CMLABNCI Chronic Myelogenous Leukemia, BCR-ABL1 PositivePTNCI Chronic Myelocytic LeukemiaSYNCI Chronic Myelogenous LeukemiaSYNCI Hematopoeitic - Chronic Myelocytic Leukemia (CML)SYNCI Chronic Granulocytic LeukemiaSYNCI Chronic Myelogenous LeukemiasSYNCI chronic myelogenous leukemiaPTNCI-GLOSSCDR0000044901 chronic granulocytic leukemiaPTNCI-GLOSSCDR0000046754
DEFINITION	A chronic myeloproliferative neoplasm characterized by the expression of the BCR-ABL1 fusion gene. It presents with neutrophilic leukocytosis. It can appear at any age, but it mostly affects middle aged and older individuals. Patients usually present with fatigue, weight loss, anemia, night sweats, and splenomegaly. If untreated, it follows a biphasic or triphasic natural course; an initial indolent chronic phase which is followed by an accelerated phase, a blast phase, or both. Allogeneic stem cell transplantation and imatinib therapy delay disease progression and prolong overall survival.NCI
code	C3174
http://linked.open...y/mesh/hasConcept	http://linked.opendata.cz/resource/mesh/concept/M0023821
is rdf:first of	nodeID://b729209 nodeID://b729210 nodeID://b729211 nodeID://b729212 nodeID://b729213 nodeID://b729214 nodeID://b729215 nodeID://b729216 nodeID://b729217 nodeID://b729218
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is sameAs of	Leukemia, Myelogenous, Chronic, BCR-ABL Positive

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