About: Platelet-Derived Growth Factor Receptor Alpha     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Platelet-Derived Growth Factor Receptor Alpha
equivalentClass
OMIM_Number
  • 173490
Semantic_Type
  • Amino Acid, Peptide, or Protein
Preferred_Name
  • Platelet-Derived Growth Factor Receptor Alpha
UMLS_CUI
  • C0290067
Legacy_Concept_Name
  • Platelet-Derived_Growth_Factor_Receptor_Alpha_Polypeptide
FULL_SYN
  • EC 2.7.10.1SYNCI
  • EC 2.7.1.112SYNCI
  • PDGFR-AlphaSYNCI
  • CD140 Antigen-Like Family Member ASYNCI
  • PDGF-R-AlphaSYNCI
  • CD140a AntigenSYNCI
  • Alpha Platelet-Derived Growth Factor ReceptorSYNCI
  • Platelet-Derived Growth Factor Alpha ReceptorSYNCI
  • Platelet-Derived Growth Factor Receptor AlphaPTNCI
  • CD140aSYNCI
  • PDGFRASYNCI
  • Platelet-Derived Growth Factor Receptor Alpha PolypeptideSYNCI
  • PDGFR-2SYNCI
  • Alpha-Type Platelet-Derived Growth Factor ReceptorSYNCI
  • Platelet-Derived Growth Factor Receptor 2SYNCI
Swiss_Prot
  • P16234
DEFINITION
  • Platelet-derived growth factor receptor alpha (1089 aa, ~123 kDa) is encoded by the human PDGFRA gene. This protein is involved in ligand binding, tyrosine phosphorylation and receptor signaling.NCI
DesignNote
  • The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. Studies in knockout mice, where homozygosity is lethal, indicate that the alpha form of the platelet-derived growth factor receptor is particularly important for kidney development since mice heterozygous for the receptor exhibit defective kidney phenotypes. (from LocusLink)
code
  • C30163
sameAs
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