About: Protein Unc-13 Homolog B

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About: Protein Unc-13 Homolog B Goto Sponge NotDistinct Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	Class
rdfs:label	Protein Unc-13 Homolog B
equivalentClass	nodeID://b640924
OMIM_Number	605836
Semantic_Type	Amino Acid, Peptide, or Protein
Preferred_Name	Protein Unc-13 Homolog B
UMLS_CUI	C1436571
Legacy_Concept_Name	UNC-13_Homolog-B_Protein
FULL_SYN	UNC-13-LikeSYNCI Protein Unc-13 Homolog BPTNCI Munc13 HomologSYNCI UNC-13 Homolog BSYNCI UNC13SYNCI munc13SYNCI Munc13-2SYNCI
Swiss_Prot	O14795
DEFINITION	Protein unc-13 homolog B (1591 aa, ~181 kDa) is encoded by the human UNC13B gene. This protein is involved in exocytosis.NCI
DesignNote	UNC13 is a putative DAG receptor and may act in a PKC-independent DAG-activated apoptosis pathway. UNC13 also appears to be a presynaptic protein that promotes synaptic vesicle priming by acting through syntaxin. Post-docking synaptic vesicle exocytosis priming requires SNARE complex formation. The default closed syntaxin configuration is incompatible with SNARE formation; the N-terminus binds the SNARE motif and occludes SNARE protein interactions. UNC13 binding to the syntaxin N-terminus may promote an open syntaxin configuration and prime synaptic vesicles for fusion.
code	C30151
http://linked.open...y/mesh/hasConcept	http://linked.opendata.cz/resource/mesh/concept/M0463591

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