About: Ibritumomab Tiuxetan     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Ibritumomab Tiuxetan
rdfs:subClassOf
Has_Target
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Ibritumomab Tiuxetan
UMLS_CUI
  • C0877880
CAS_Registry
  • 206181-63-7
FDA_UNII_Code
  • 4Q52C550XK
Contributing_Source
  • FDA
ALT_DEFINITION
  • A monoclonal antibody that is used to treat certain types of B-cell non-Hodgkin lymphoma and is being studied in the treatment and detection of other types of B-cell tumors. Monoclonal antibodies are made in the laboratory and can locate and bind to substances in the body, including cancer cells. Ibritumomab binds to the protein called CD20, which is found on B cells. It is linked to the compound tiuxetan. This allows certain radioisotopes to be attached before it is given to a patient. It is a type of monoclonal antibody-chelator conjugate.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 43080
PDQ_Closed_Trial_Search_ID
  • 43080
Chemical_Formula
  • C23H32N5O10S
Legacy_Concept_Name
  • Ibritumomab_Tiuxetan
FULL_SYN
  • IBRITUMOMAB TIUXETANPTFDA4Q52C550XK
  • ibritumomab tiuxetanPTNCI-GLOSSCDR0000574728
  • ZevalinPTNCI-GLOSSCDR0000579649
  • ZevalinBRNCI
  • IDEC-129CNNCI
  • IDEC-2B8CNNCI
  • Ibritumomab TiuxetanPTNCI
DEFINITION
  • An immunoconjugate of the monoclonal antibody ibritumomab conjugated with the linker-chelator tiuxetan, a high affinity, conformationally restricted chelation site for radioisotopes. When bound to indium In 111 or yttrium Y 90, ibritumomab tiuxetan, targeting the CD20 antigen on B cell surfaces, specifically delivers a potentially cytotoxic dose of radiation to B lymphocytes. Ibritumomab is a murine IgG1 kappa monoclonal antibody directed against the CD20 antigen, which is found on the surface of normal and malignant B lymphocytes.NCI
code
  • C29981
sameAs
http://linked.open...y/mesh/hasConcept
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