About: Receptor-Interacting Serine/Threonine-Protein Kinase 3     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Receptor-Interacting Serine/Threonine-Protein Kinase 3
equivalentClass
OMIM_Number
  • 605817
Semantic_Type
  • Amino Acid, Peptide, or Protein
Preferred_Name
  • Receptor-Interacting Serine/Threonine-Protein Kinase 3
UMLS_CUI
  • C1431910
Legacy_Concept_Name
  • Receptor-Interacting_Serine-Threonine_Protein_Kinase-3
FULL_SYN
  • EC 2.7.11.1SYNCI
  • RIP-Like Protein Kinase 3SYNCI
  • Receptor-Interacting Serine/Threonine Protein Kinase 3SYNCI
  • Receptor-Interacting Serine/Threonine-Protein Kinase 3PTNCI
  • RIP3SYNCI
  • RIP-3SYNCI
  • RIPK3SYNCI
  • Receptor-Interacting Protein 3SYNCI
Swiss_Prot
  • Q9Y572
DEFINITION
  • Receptor-interacting serine/threonine-protein kinase 3 (518 aa, ~57 kDa) is encoded by the human RIPK3 gene. This protein plays a role in the induction of necrosis.NCI
DesignNote
  • RIPK3 colocalizes in the mitochondrion with RIPK1. RIPK3 is recruited to the TNFR1 complex in a RIPK1-dependent manner and interacts with TRAF2. The RIPK3 C-terminus is required to induce apoptosis through the activation of some or all caspases and also appears to activate NFKB. RIPK3 can stimulate NFKB nuclear translocation.
code
  • C29873
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