About: Triphenylethylene     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Triphenylethylene
rdfs:subClassOf
Semantic_Type
  • Organic Chemical
Preferred_Name
  • Triphenylethylene
NSC_Code
  • 17535
UMLS_CUI
  • C0077252
CAS_Registry
  • 58-72-0
Legacy_Concept_Name
  • Triphenylethylene
FULL_SYN
  • TriphenylethylenePTNCI
DEFINITION
  • the core chemical structure of a number of related anti-estrogen compounds. The triphenylethylene antiestrogens, which include idoxifene, toremifene, chlorotrianisene, raloxifene and tamoxifen, act at the level of the estrogen receptor, triggering inhibition or stimulation of estrogen-dependent gene transcription and cellular physiology. Triphenylethylenes were initially developed for the treatment of estrogen-dependent breast cancers. Selective estrogen receptor modulators (SERMs) such as raloxifene and tamoxifen represent triphenylethylene derivatives that affect transcriptional regulation through modulation of specific alpha and beta estrogen receptors that are differentially expressed in various normal and neoplastic tissues. (NCI04)NCI
code
  • C29863
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