About: Inositol 1,4,5-Triphosphate Receptor Type 1     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Inositol 1,4,5-Triphosphate Receptor Type 1
equivalentClass
OMIM_Number
  • 147265
Semantic_Type
  • Amino Acid, Peptide, or Protein
  • Receptor
Preferred_Name
  • Inositol 1,4,5-Triphosphate Receptor Type 1
UMLS_CUI
  • C0626645
Legacy_Concept_Name
  • Inositol-1-4-5-Triphosphate_Receptor_Type-1
FULL_SYN
  • IP3 Receptor Isoform 1SYNCI
  • Inositol 1,4,5-Triphosphate Receptor Type 1PTNCI
  • Type 1 Inositol 1,4,5-Trisphosphate ReceptorSYNCI
  • IP3RSYNCI
  • IP3R1SYNCI
  • InsP3R1SYNCI
  • Type 1 InsP3 ReceptorSYNCI
Swiss_Prot
  • Q14643
DEFINITION
  • Widely expressed by human ITPR1 Gene (InsP3R Family) as 8 potential alternative isoforms, 2758-aa 314-kDa integral endoplasmic reticulum membrane protein Inositol 1,4,5-Triphosphate Receptor Type 1 mediates release of intracellular calcium in response to second messenger inositol 1,4,5-trisphosphate. A likely homotetramer, the receptor contains 5 MIR domains, a large N-terminal ligand-binding cytoplasmic region, and central modulatory sites immediately upstream of the C-terminal calcium channel. Calcium appears to inhibit ligand binding to the receptor, perhaps by interaction with an inhibitory calcium-binding protein. Phosphorylation may prevent ligand-induced opening of the calcium channel. ITPR1 interacts with TRPC4 and is phosphorylated by c-AMP kinase. (NCI)NCI
code
  • C29754
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