About: General Transcription Factor IIH Subunit 1     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • General Transcription Factor IIH Subunit 1
equivalentClass
OMIM_Number
  • 189972
Semantic_Type
  • Amino Acid, Peptide, or Protein
  • Biologically Active Substance
Preferred_Name
  • General Transcription Factor IIH Subunit 1
UMLS_CUI
  • C1333805
Legacy_Concept_Name
  • General_Transcription_Factor-IIH1-62kDa
FULL_SYN
  • TFIIH Basal Transcription Factor Complex p62 SubunitSYNCI
  • General Transcription Factor IIH1SYNCI
  • General Transcription Factor IIH Polypeptide 1SYNCI
  • GTF2H1SYNCI
  • General Transcription Factor IIH1 62kDaSYNCI
  • BTF2 p62SYNCI
  • BTF2-p62SYNCI
  • Basic Transcription Factor 62kDa SubunitSYNCI
  • General Transcription Factor IIH Subunit 1PTNCI
Swiss_Prot
  • P32780
DEFINITION
  • General transcription factor IIH subunit 1 (548 aa, ~62 kDa) is encoded by the human GTF2H1 gene. This protein is involved in the modulation of both RNA polymerase II-mediated transcription and nucleotide excision repair.NCI
DesignNote
  • Expressed in testis by human GTF2H1 Gene, General Transcription Factor IIH1 62kDa is a subunit of TFIIH, a multisubunit factor of at least 10 proteins involved in transcription, nucleotide excision repair, and cell cycle regulation. p62 is one of six subunits that constitutes the TFIIH core; the holoenzyme contains the ternary kinase CAK complex. Lacking any known motifs or enzymatic activity p62 may have only an architectural role.
code
  • C29680
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