About: Proto-Oncogene FRAT1 Protein

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Proto-Oncogene FRAT1 Protein Goto Sponge NotDistinct Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	Class
rdfs:label	Proto-Oncogene FRAT1 Protein
rdfs:subClassOf	Tumor-Related Protein nodeID://b705723 nodeID://b705724
OMIM_Number	602503
Semantic_Type	Amino Acid, Peptide, or Protein Biologically Active Substance
Preferred_Name	Proto-Oncogene FRAT1 Protein
UMLS_CUI	C1335561
Legacy_Concept_Name	Proto-Oncogene-FRAT1_Protein
FULL_SYN	FRAT1SYNCI Proto-Oncogene FRAT1 ProteinPTNCI Frequently Rearranged in Advanced T-Cell Lymphomas ProteinSYNCI
Swiss_Prot	Q92837
DEFINITION	Encoded as same the isoform by two alternative transcripts of human FRAT1 Gene (GSK-3-Binding Protein Family), 279-aa 29-kDa Proto-Oncogene FRAT1 Protein is 79% identical to mouse Frat1, contains 3 conserved regions, and appears to participate in the WNT signaling pathway. FRAT1 binds DVL1. FRAT1 may bind GSK-3, preventing GSK-3-dependent phosphorylations and may inhibit beta-catenin phosphorylation, preventing its degradation by the ubiquitin-proteasome pathway. GBP, FRAT1, and FRAT2 contain similar sequences. GSK3-binding and -inhibitory activities of FRAT2 reside in the conserved C-terminal domain III. FRAT1 may play a role in tumor progression and lymphomagenesis with PIM1 and MYC. (NCI)NCI
code	C29585
http://linked.open...y/mesh/hasConcept	http://linked.opendata.cz/resource/mesh/concept/M0467648

Faceted Search & Find service v1.16.118 as of Jun 21 2024

Alternative Linked Data Documents: ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3240 as of Jun 21 2024, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (126 GB total memory, 116 GB memory in use)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software