About: Recombinant Vaccinia-PSA(L155)-TRICOM Vaccine     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Recombinant Vaccinia-PSA(L155)-TRICOM Vaccine
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
  • Virus
Preferred_Name
  • Recombinant Vaccinia-PSA(L155)-TRICOM Vaccine
NSC_Code
  • 717170
OLD_PARENT
  • Vaccinia-TRICOM_Vaccine
OLD_ROLE
  • Chemical_Or_Drug_Has_Mechanism_Of_Action some 'Gene Regulation Process'
  • Chemical_Or_Drug_Affects_Cell_Type_Or_Tissue some 'Cytotoxic T-Lymphocyte'
  • Chemical_Or_Drug_Has_Physiologic_Effect some 'T-Cell Activation'
  • Chemical_Or_Drug_Has_Physiologic_Effect some Immunopotentiation
UMLS_CUI
  • C1515695
Concept_Status
  • Retired_Concept
OLD_ASSOCIATION
  • 'Prostate-Specific Antigen'
Legacy_Concept_Name
  • rVaccinia-PSA_L155_TRICOM
FULL_SYN
  • rVaccinia-PSA(L155)-TRICOM VaccineSYNCI
  • Recombinant Vaccinia-PSA(L155)-TRICOM VaccinePTNCI
  • Recombinant Vaccinia-PSA(L155)/TRICOMSYNCI
  • PROSTVAC-V/TRICOMSYNCI
DEFINITION
  • A recombinant vaccinia virus encoding a modified peptide of the prostate-specific antigen (PSA) with a leucine substitution at position 155, and a TRIad of COstimulatory Molecules (B7-1, ICAM-1 and LFA-3). Vaccination with this viral vaccine may enhance antigen presentation and may activate cytotoxic T-cells against PSA-expressing tumor cells.NCI
DesignNote
  • Fri Mar 30 16:36:04 EDT 2012 - See 'Vaccinia-PSA-TRICOM_Vaccine'
code
  • C29565
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