About: Uniroyal Compound-38

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Attributes	Values
rdf:type	Class
rdfs:label	Uniroyal Compound-38
rdfs:subClassOf	Non-Nucleoside Reverse Transcriptase Inhibitors
Semantic_Type	Pharmacologic Substance
Preferred_Name	Uniroyal Compound-38
PubMedID_Primary_Reference	9772165
NSC_Code	615985
UMLS_CUI	C0753797
CAS_Registry	135812-34-9
Legacy_Concept_Name	Uniroyal_Compound
FULL_SYN	Uniroyal Jr.SYNCI UC38CNNCI UC-38CNNCI 1-methylethyl-2-chloro-5-[[5,6-dihydro-2-methyl- 1, 4-oxathiin-3-yl-carbonyl]-amino]benzoateSNNCI Uniroyal Compound-38PTNCI 2-Chloro-5-(((1-methylethoxy)thioxomethyl)amino)benzoic acidSNNCI
DEFINITION	A second generation non-nucleoside reverse transcriptase inhibitor derivative of oxathiin carboxanilide. Uniroyal compound 38 has activity against a wide range of biologically diverse laboratory and clinical strains of HIV-1 but is inactive against HIV-2.NCI
DesignNote	Compounds owned by Uniroyal, related to UC10 have been shown to be active against virus containing all five of the major mutations that confer resistance to other NNRTIs. Uniroyal's NNRTIs are currently named UC-10 (NSC 645129), UC-40, UC-42, UC-84 (NSC 615985) and UC-781. http://hiv-web.lanl.gov/content/hiv-db/REVIEWS/Mellors.html
code	C29528
http://linked.open...y/mesh/hasConcept	http://linked.opendata.cz/resource/mesh/concept/M0221692

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