About: Transferrin Receptor-Targeted Liposomal p53 cDNA

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Attributes	Values
rdf:type	Class
rdfs:label	Transferrin Receptor-Targeted Liposomal p53 cDNA
rdfs:subClassOf	Gene Transfer or Gene Delivery Agent
Semantic_Type	Pharmacologic Substance
Preferred_Name	Transferrin Receptor-Targeted Liposomal p53 cDNA
NSC_Code	709399
NCI_META_CUI	CL319865
PDQ_Open_Trial_Search_ID	551892
PDQ_Closed_Trial_Search_ID	551892
Legacy_Concept_Name	Synerlip_p53
FULL_SYN	Synerlip p53SYNCI SGT-53ABNCI Transferrin Receptor-Targeted Liposomal p53 cDNAPTNCI
DEFINITION	A cationic liposomal, tumor-targeting p53 (TP53) gene delivery system with potential anti-tumor activity. Transferrin receptor-targeted liposomal p53 cDNA contains plasmid DNA encoding the tumor suppressor protein p53 packaged in membrane-like liposome capsules that are complexed with anti-transferrin receptor single-chain antibody (TfRscFv). Upon systemic administration, the anti-TfRscFv selectively binds to tumor cells expressing transferrin receptors. The p53 plasmid is delivered into the nucleus and as a result, p53 protein is produced in tumor cells that have altered p53 function. This results in the restoration of normal cell growth control mechanisms as well as normal response mechanisms to DNA damage.NCI
code	C29474

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