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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Simvastatin
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Simvastatin
NSC_Code
  • 633782
UMLS_CUI
  • C0074554
CAS_Registry
  • 79902-63-9
FDA_UNII_Code
  • AGG2FN16EV
Contributing_Source
  • FDA
PDQ_Open_Trial_Search_ID
  • 455226
PDQ_Closed_Trial_Search_ID
  • 455226
Chemical_Formula
  • C25H38O5
Legacy_Concept_Name
  • Simvastatin
CHEBI_ID
  • CHEBI:9150
FULL_SYN
  • SynvinolinSYNCI
  • SimvastatinPTNCI
  • [1S-[1alpha,3alpha,7beta,8beta(2S*,4S*),8abeta]]-1,2,3,7,8,8a-Hexahydro-3,7-dimethyl-8-[2-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl]-1-naphthalenyl 2,2-dimethylbutanoateSNNCI
  • SimvastatinPTDCP02582
  • ZocorBRNCI
  • MK 733CNNCI
  • SIMVASTATINPTFDAAGG2FN16EV
DEFINITION
  • A lipid-lowering agent derived synthetically from a fermentation product of the fungus Aspergillus terreus. Hydrolyzed in vivo to an active metabolite, simvastatin competitively inhibits hepatic hydroxymethyl-glutaryl coenzyme A (HMG-CoA) reductase, the enzyme which catalyzes the conversion of HMG-CoA to mevalonate, a key step in cholesterol synthesis. This agent lowers plasma cholesterol and lipoprotein levels, and modulates immune responses by suppressing MHC II (major histocompatibility complex II) on interferon gamma-stimulated, antigen-presenting cells such as human vascular endothelial cells. (NCI04)NCI
code
  • C29454
sameAs
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