About: SJG-136     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • SJG-136
rdfs:subClassOf
Has_Target
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • SJG-136
NSC_Code
  • 694501
UMLS_CUI
  • C1519143
ALT_DEFINITION
  • A substance that is being studied in the treatment of cancer. It belongs to the family of drugs called DNA cross-linking agents.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 415963
PDQ_Closed_Trial_Search_ID
  • 415963
Legacy_Concept_Name
  • SJG-136
FULL_SYN
  • SJG-136PTNCI-GLOSSCDR0000423254
  • Pyrrolobenzodiazepine DimerSYNCI
  • SJG136CNNCI
  • SJG-136PTNCI
  • 8,8'-[[(propane-1,3-diyl)dioxy]bis[(11aS)-7-methoxy-2-methylidene-1,2,3,11a-tetrahydro-5H-pyrrolo[2,1-c][1,4]benzodiazepin-5-one]SNNCI
DEFINITION
  • A pyrrolobenzodiazepine dimer with potential antineoplastic activity. SJG-136 binds to the minor groove of DNA and induces interstrand cross-links between two N-2 guanine positions, thereby inhibiting DNA replication and transcription. With a preference for binding to purine-GATC-pyrimidine sequences, SJG-136 adducts do not appear to be subject to p53-mediated DNA excision repair mechanisms. (NCI05)NCI
code
  • C29435
http://linked.open...y/mesh/hasConcept
Faceted Search & Find service v1.16.118 as of Jun 21 2024


Alternative Linked Data Documents: ODE     Content Formats:   [cxml] [csv]     RDF   [text] [turtle] [ld+json] [rdf+json] [rdf+xml]     ODATA   [atom+xml] [odata+json]     Microdata   [microdata+json] [html]    About   
This material is Open Knowledge   W3C Semantic Web Technology [RDF Data] Valid XHTML + RDFa
OpenLink Virtuoso version 07.20.3240 as of Jun 21 2024, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (126 GB total memory, 46 GB memory in use)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software