About: SJG-136     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • SJG-136
rdfs:subClassOf
Has_Target
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • SJG-136
NSC_Code
  • 694501
UMLS_CUI
  • C1519143
ALT_DEFINITION
  • A substance that is being studied in the treatment of cancer. It belongs to the family of drugs called DNA cross-linking agents.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 415963
PDQ_Closed_Trial_Search_ID
  • 415963
Legacy_Concept_Name
  • SJG-136
FULL_SYN
  • SJG-136PTNCI-GLOSSCDR0000423254
  • Pyrrolobenzodiazepine DimerSYNCI
  • SJG136CNNCI
  • SJG-136PTNCI
  • 8,8'-[[(propane-1,3-diyl)dioxy]bis[(11aS)-7-methoxy-2-methylidene-1,2,3,11a-tetrahydro-5H-pyrrolo[2,1-c][1,4]benzodiazepin-5-one]SNNCI
DEFINITION
  • A pyrrolobenzodiazepine dimer with potential antineoplastic activity. SJG-136 binds to the minor groove of DNA and induces interstrand cross-links between two N-2 guanine positions, thereby inhibiting DNA replication and transcription. With a preference for binding to purine-GATC-pyrimidine sequences, SJG-136 adducts do not appear to be subject to p53-mediated DNA excision repair mechanisms. (NCI05)NCI
code
  • C29435
http://linked.open...y/mesh/hasConcept
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