About: Sangivamycin Hydrochloride     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Sangivamycin Hydrochloride
rdfs:subClassOf
Semantic_Type
  • Amino Acid, Peptide, or Protein
  • Pharmacologic Substance
Preferred_Name
  • Sangivamycin Hydrochloride
NSC_Code
  • 143648
UMLS_CUI
  • C1519180
CAS_Registry
  • 21090-35-7
Legacy_Concept_Name
  • Sangivamycin_Hydrochloride
FULL_SYN
  • Sangivamycin HydrochloridePTNCI
DEFINITION
  • The salt of a deaza-adenosine antibiotic isolated from the bacterium Streptomyces rimosus with potent cytotoxic properties. Sangivamycin inhibits protein kinase C (PKC), a signaling mediator important for cell growth and differentiation. This agent may also interfere with protein synthesis by inhibiting the formation of complexes essential to the initiation of protein synthesis and DNA synthesis. (NCI04)NCI
code
  • C29417
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