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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Ramipril
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Ramipril
UMLS_CUI
  • C0878061
CAS_Registry
  • 87333-19-5
FDA_UNII_Code
  • L35JN3I7SJ
Contributing_Source
  • FDA
Chemical_Formula
  • C23H32N2O5
Legacy_Concept_Name
  • Ramipril
CHEBI_ID
  • CHEBI:8774
FULL_SYN
  • RAMIPRILPTFDAL35JN3I7SJ
  • AltaceBRNCI
  • RamiprilPTNCI
  • RamiprilPTDCP32054
DEFINITION
  • A prodrug and nonsulfhydryl angiotensin converting enzyme (ACE) inhibitor with antihypertensive activity. Ramipril is converted in the liver by de-esterification into its active form ramiprilat, which inhibits ACE, thereby blocking the conversion of angiotensin I to angiotensin II. This abolishes the potent vasoconstrictive actions of angiotensin II and leads to vasodilatation. This agent also causes an increase in bradykinin levels and a decrease in angiotensin II-induced aldosterone secretion by the adrenal cortex, thereby promoting diuresis and natriuresis.NCI
code
  • C29411
sameAs
http://linked.open...y/mesh/hasConcept
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