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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Rabeprazole
rdfs:subClassOf
Has_Salt_Form
Concept_In_Subset
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Rabeprazole
UMLS_CUI
  • C0378482
CAS_Registry
  • 117976-89-3
FDA_UNII_Code
  • 32828355LL
Contributing_Source
  • FDA
Chemical_Formula
  • C18H21N3O3S
Legacy_Concept_Name
  • Rabeprazole
CHEBI_ID
  • CHEBI:8768
FULL_SYN
  • RabeprazolePTNCI
  • 2-(((4-(3-Methoxypropoxy)-3-methyl-2-pyridinyl)methyl)sulfinyl)-1H-benzimidazoleSNNCI
  • LY307640CNNCI
  • RABEPRAZOLEPTFDA32828355LL
DEFINITION
  • An alpha-pyridylmethylsulfinyl benzimidazole and a selective and irreversible proton pump inhibitor with antisecretory property. Rabeprazole enters the parietal cell and accumulates in the acidic secretory canaliculi where the agent is activated by a proton-catalyzed process that results in the formation of a thiophilic sulfonamide or sulfenic acid. The activated rabeprazole forms covalent bonds with the sulfhydryl amino acids cysteine on the extracellular domain of the proton pump (H+/K+ ATPase) at the secretory surface, thereby inhibiting the transport of hydrogen ions, via exchange with potassium ions, into the gastric lumen. Binding to cysteine 813, in particular, is essential for inhibition of gastric acid production.NCI
code
  • C29410
sameAs
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