About: Propantheline Bromide     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Propantheline Bromide
rdfs:subClassOf
Has_Free_Acid_Or_Base_Form
Concept_In_Subset
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Propantheline Bromide
UMLS_CUI
  • C0033448
CAS_Registry
  • 50-34-0
FDA_UNII_Code
  • UX9Z118X9F
Contributing_Source
  • FDA
Chemical_Formula
  • C23H30NO3.Br
Legacy_Concept_Name
  • Propantheline_Bromide
FULL_SYN
  • PROPANTHELINE BROMIDEPTFDAUX9Z118X9F
  • Propantheline BromidePTNCI
DEFINITION
  • The bromide salt form of propantheline, a quaternary ammonium compound structurally related to belladonna alkaloids. Propantheline bromide competitively antagonizes acetylcholine activity mediated by muscarinic receptors at neuroeffector sites on smooth muscle and exocrine gland cells. An aspartic acid residue present in the N-terminal portion of the third trans-membrane helix of the muscarinic receptor is believed to form an ionic bond with the tertiary or quaternary nitrogen of the antagonist. Antagonism leads to a reduction of exocrine glands secretions and to relax bronchial muscle and reduce tone and motility of intestinal smooth muscle.NCI
code
  • C29383
sameAs
http://linked.open...y/mesh/hasConcept
is Has_Salt_Form of
is sameAs of
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