About: Pioglitazone Hydrochloride     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Pioglitazone Hydrochloride
rdfs:subClassOf
Has_Free_Acid_Or_Base_Form
Concept_In_Subset
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Pioglitazone Hydrochloride
UMLS_CUI
  • C0872972
CAS_Registry
  • 112529-15-4
FDA_UNII_Code
  • JQT35NPK6C
Contributing_Source
  • FDA
ALT_DEFINITION
  • A drug that is used to treat type 2 diabetes and is being studied in the prevention of head and neck cancer. It may be able to stop leukoplakia (a condition affecting the mouth ) from developing into cancer. It is a type of thiazolidinedione.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 398145
PDQ_Closed_Trial_Search_ID
  • 398145
Chemical_Formula
  • C19H20N2O3S.HCl
Legacy_Concept_Name
  • Pioglitazone
FULL_SYN
  • ActosPTNCI-GLOSSCDR0000413938
  • Pioglitazone HydrochloridePTNCI
  • ActosBRNCI
  • PIOGLITAZONE HYDROCHLORIDEPTFDAJQT35NPK6C
  • Pioglitazone.HClPTDCP20324
DEFINITION
  • The hydrochloride salt of an orally-active thiazolidinedione with antidiabetic properties and potential antineoplastic activity. Pioglitazone activates peroxisome proliferator-activated receptor gamma (PPAR-gamma), a ligand-activated transcription factor, thereby inducing cell differentiation and inhibiting cell growth and angiogenesis. This agent also modulates the transcription of insulin-responsive genes, inhibits macrophage and monocyte activation, and stimulates adipocyte differentiation. (NCI05)NCI
code
  • C29367
sameAs
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