About: Talotrexin

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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	Class
rdfs:label	Talotrexin
rdfs:subClassOf	Dihydrofolate Reductase Inhibitor Folate Antagonist nodeID://b700991 nodeID://b700992 nodeID://b700993 nodeID://b700994 nodeID://b700995
Has_Salt_Form	Talotrexin Ammonium
Concept_In_Subset	FDA Established Names and Unique Ingredient Identifier Codes Terminology
Semantic_Type	Pharmacologic Substance
Preferred_Name	Talotrexin
NSC_Code	623017
UMLS_CUI	C0251361
CAS_Registry	113857-87-7
FDA_UNII_Code	A8E516A20K
Contributing_Source	FDA
ALT_DEFINITION	A substance that is being studied in the treatment of leukemia and some other types of cancer. It belongs to the family of drugs called antifolates.NCI-GLOSS
Chemical_Formula	C27H27N9O6
Legacy_Concept_Name	PT523
FULL_SYN	talotrexinPTNCI-GLOSSCDR0000455149 PT523CNNCI TALOTREXINPTFDAA8E516A20K N(alpha)-(4-Amino-4-deoxypteroyl)-N(delta)-hemiphthaloyl-L-ornithineSNNCI TalopterinSYNCI TalotrexinPTNCI
DEFINITION	An antimetabolite analogue of aminopterin with potential antineoplastic activity. As a folate antagonist, talotrexin binds to and inhibits the function of dihydrofolate reductase, resulting in the inhibition of folate metabolism, DNA synthesis, and cell division. Hydrosoluble, talotrexin is actively transported into cells by the reduced folate carrier (RFC) and, therefore, is unlikely to be associated with P-glycoprotein-mediated multidrug resistance.NCI
code	C29341
http://linked.open...y/mesh/hasConcept	http://linked.opendata.cz/resource/mesh/concept/M0227095
is Has_Free_Acid_Or_Base_Form of	Talotrexin Ammonium

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