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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Oxycodone
rdfs:subClassOf
Has_Salt_Form
Concept_In_Subset
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Oxycodone
NSC_Code
  • 19043
UMLS_CUI
  • C0030049
CAS_Registry
  • 76-42-6
FDA_UNII_Code
  • CD35PMG570
Contributing_Source
  • FDA
Chemical_Formula
  • C18H21NO4
Legacy_Concept_Name
  • Oxycodone
CHEBI_ID
  • CHEBI:7852
FULL_SYN
  • Oxycodone SRSYNCI
  • 4,5-Epoxy-14-hydroxy-3-methoxy-17-methylmorphinan-6-oneSNNCI
  • OXYCODONEPTFDACD35PMG570
  • OxycodonePTNCI
DEFINITION
  • A semi-synthetic, morphine-like opioid alkaloid with analgesic activity. Oxycodone exerts its analgesic activity by binding to the mu-receptors in the central nervous system (CNS), thereby mimicking the effects of endogenous opioids. Binding of the opiate receptor stimulates the exchange of GTP for GDP on the G-protein complex and inhibits adenylate cyclase, thereby preventing cAMP production. Subsequently, the release of nociceptive neurotransmitters, such as substance P, gamma-aminobutyric acid (GABA), dopamine, acetylcholine, and noradrenaline, is inhibited. Oxycodone also inhibits the release of vasopressin, somatostatin, insulin, and glucagon. In addition, oxycodone closes N-type voltage-gated calcium channels and opens G-protein-coupled inwardly rectifying potassium channels resulting in hyperpolarization and reduction of neuronal excitability.NCI
code
  • C29309
sameAs
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