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AttributesValues
rdf:type
rdfs:label
  • Mycophenolate
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Mycophenolate
UMLS_CUI
  • C0883242
Legacy_Concept_Name
  • Mycophenolate
CHEBI_ID
  • CHEBI:62932
FULL_SYN
  • MycophenolatePTNCI
DEFINITION
  • The morpholinoethyl ester of mycophenolic acid (MPA). As an immunosuppressive agent in vivo, the active metabolite mycophenolate reversibly inhibits inosine 5'-monophosphate dehydrogenase (IMPDH), an enzyme involved in the de novo synthesis of guanine nucleotides, thereby retarding T-cell and B-cell proliferation. MPA displays high lymphocyte specificity and cytotoxicity because lymphocyte metabolism is highly dependent on both salvage and de novo synthesis of guanine nucleotides. (NCI04)NCI
code
  • C29272
is sameAs of
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