About: Losartan/Hydrochlorothiazide     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Losartan/Hydrochlorothiazide
rdfs:subClassOf
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Losartan/Hydrochlorothiazide
UMLS_CUI
  • C0721010
Legacy_Concept_Name
  • Losartan_Hydrochlorothiazide
FULL_SYN
  • HyzaarBRNCI
  • Losartan/HydrochlorothiazidePTNCI
DEFINITION
  • A combination preparation of a synthetic angiotensin II antagonist and a diuretic thiazide, with antihypertensive activity. Losartan, and its metabolite, selectively and competitively block the binding of angiotensin II to the angiotensin II (AT1) receptor. As a result, angiotensin II-AT1 mediated physiological effects such as vasoconstriction and stimulation of aldosterone synthesis and secretion, which regulates extracellular sodium concentration, are blocked. Hydrochlorothiazide inhibits electrolytes reabsorption via binding to Na-Cl cotransporter on the renal distal tubular, thereby increasing excretion of sodium, potassium, chloride, bicarbonate and water. Both agents lead to a reduction in blood pressure.NCI
code
  • C29166
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