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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Lisinopril
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Lisinopril
UMLS_CUI
  • C0065374
CAS_Registry
  • 83915-83-7
FDA_UNII_Code
  • E7199S1YWR
Contributing_Source
  • FDA
ALT_DEFINITION
  • A drug used to treat high blood pressure and certain heart conditions. It is also being studied in the prevention and treatment of side effects caused by some anticancer drugs. It blocks certain enzymes that cause blood vessels to constrict (narrow). It is a type of angiotensin-converting enzyme (ACE) inhibitor.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 658710
PDQ_Closed_Trial_Search_ID
  • 658710
Chemical_Formula
  • C21H31N3O5.2H2O
Legacy_Concept_Name
  • Lisinopril
CHEBI_ID
  • CHEBI:6503
FULL_SYN
  • lisinoprilPTNCI-GLOSSCDR0000662967
  • ZestrilPTNCI-GLOSSCDR0000662970
  • ZestrilBRNCI
  • N2-[(1S)-1-Carboxy-3-phenylpropyl]-L-lysyl-L-proline, DihydratePTDCP32058
  • LISINOPRILPTFDAE7199S1YWR
  • PrinivilPTNCI-GLOSSCDR0000662968
  • PrinivilBRNCI
  • LisinoprilPTNCI
DEFINITION
  • An orally bioavailable, long-acting angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity. Lisinopril, a synthetic peptide derivative, specifically and competitively inhibits ACE, which results in a decrease in the production of the potent vasoconstrictor angiotensin II and, so, diminished vasopressor activity. In addition, angiotensin II-stimulated aldosterone secretion by the adrenal cortex is decreased which results in a decrease in sodium and water retention and an increase in serum potassium.NCI
code
  • C29159
sameAs
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