About: Isosorbide Dinitrate

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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	Class
rdfs:label	Isosorbide Dinitrate
rdfs:subClassOf	Vasodilating Agent
Has_Free_Acid_Or_Base_Form	ISOSORBIDE
Concept_In_Subset	FDA Established Names and Unique Ingredient Identifier Codes Terminology
Semantic_Type	Organic Chemical Pharmacologic Substance
Preferred_Name	Isosorbide Dinitrate
NSC_Code	80038
UMLS_CUI	C0022252
CAS_Registry	87-33-2
FDA_UNII_Code	IA7306519N
Contributing_Source	FDA
Chemical_Formula	C6H8N2O8
Legacy_Concept_Name	Isosorbide_Dinitrate
CHEBI_ID	CHEBI:6061
FULL_SYN	ISOSORBIDE DINITRATEPTFDAIA7306519N IsordilBRNCI Isosorbide DinitratePTNCI
DEFINITION	The dinitrate salt form of isosorbide, an organic nitrate with vasodilator activity. Isosorbide dinitrate relaxes vascular smooth muscle by formation of the free radical nitric oxide (NO), which is identical to the endothelium-derived relaxing factor (EDRF). NO activates guanylyl cyclase, thereby increasing the synthesis of cGMP within smooth muscle, resulting in dephosphorylation of light chain myosin and relaxation of peripheral arteries and veins. In addition, isosorbide dinitrate relaxes coronary arteries, thereby increasing the blood circulation through the ischemic area. (NCI05)NCI
code	C29134
sameAs	ISOSORBIDE DINITRATE ISOSORBIDE DINITRATE
http://linked.open...y/mesh/hasConcept	http://linked.opendata.cz/resource/mesh/concept/M0011788
is Has_Salt_Form of	ISOSORBIDE
is sameAs of	ISOSORBIDE DINITRATE ISOSORBIDE DINITRATE ISOSORBIDE DINITRATE

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