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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Gemfibrozil
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Gemfibrozil
UMLS_CUI
  • C0017245
CAS_Registry
  • 25812-30-0
FDA_UNII_Code
  • Q8X02027X3
Contributing_Source
  • FDA
Chemical_Formula
  • C15H22O3
Legacy_Concept_Name
  • Gemfibrozil
CHEBI_ID
  • CHEBI:5296
FULL_SYN
  • GemfibrozilPTNCI
  • GemfibrozilPTDCP06549
  • LopidBRNCI
  • GEMFIBROZILPTFDAQ8X02027X3
DEFINITION
  • A fibric acid derivative with hypolipidemic effects. Gemfibrozil interacts with peroxisome proliferator-activated receptors (PPARalpha) resulting in PPARalpha-mediated stimulation of fatty acid oxidation and an increase in lipoprotein lipase (LPL) synthesis. This enhances triglyceride-rich lipoprotein clearance and reduces the expression of apolipoprotein C-III (apoC-III). The reduction in hepatic production of apoC-III results in subsequent reduction of serum levels of very-low-density-lipoprotein cholesterol (VLDL-C). In addition, gemfibrozil-mediated PPARalpha stimulation of apoA-I and apoA-II expression results in an increase in high-density lipoprotein cholesterol (HDL-C).NCI
code
  • C29071
sameAs
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