About: Fluticasone Propionate     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Fluticasone Propionate
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
  • Steroid
Preferred_Name
  • Fluticasone Propionate
UMLS_CUI
  • C0117996
CAS_Registry
  • 80474-14-2
FDA_UNII_Code
  • O2GMZ0LF5W
Contributing_Source
  • FDA
Chemical_Formula
  • C25H31F3O5S
Legacy_Concept_Name
  • Fluticasone_Propionate
CHEBI_ID
  • CHEBI:31441
FULL_SYN
  • Fluticasone PropionatePTNCI
  • (6alpha,11beta,16alpha,17alpha)-6,9-Difluoro-11-hydroxy-16-methyl-3-oxo-17-(1-oxopropoxy)androsta-1,4-diene-17-carbothioic Acid, S-(Fluoromethyl) EsterSNNCI
  • FLUTICASONE PROPIONATEPTFDAO2GMZ0LF5W
  • FlonaseBRNCI
  • FloventBRNCI
  • Fluticasone PropionatePTDCP50239
DEFINITION
  • The propionate salt form of fluticasone, a synthetic trifluorinated glucocorticoid receptor agonist with antiallergic, antiinflammatory and antipruritic effects. Binding and activation of the glucocorticoid receptor results in the activation of lipocortin that in turn inhibits cytosolic phospholipase A2, which triggers cascade of reactions involved in synthesis of inflammatory mediators, such as prostaglandins and leukotrienes. Secondly, mitogen-activated protein kinase (MAPK) phosphatase 1 is induced, thereby leads to dephosphorylation and inactivation of Jun N-terminal kinase directly inhibiting c-Jun mediated transcription. Finally, transcriptional activity of nuclear factor (NF)-kappa-B is blocked, thereby inhibits the transcription of cyclooxygenase 2, which is essential for prostaglandin production.NCI
code
  • C29061
sameAs
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