About: Flurazepam Hydrochloride     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Flurazepam Hydrochloride
rdfs:subClassOf
Has_Free_Acid_Or_Base_Form
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Flurazepam Hydrochloride
NSC_Code
  • 78559
UMLS_CUI
  • C0242293
CAS_Registry
  • 1172-18-5
FDA_UNII_Code
  • 756RDM536M
Contributing_Source
  • FDA
Chemical_Formula
  • C21H23ClFN3O.2HCl
Legacy_Concept_Name
  • Flurazepam
FULL_SYN
  • Insumin DihydrochlorideSYNCI
  • Flurazepam HydrochloridePTNCI
  • Flurazepam DihydrochlorideSYNCI
  • ID480CNNCI
  • FLURAZEPAM HYDROCHLORIDEPTFDA756RDM536M
  • LinzacBRNCI
  • SomlanBRNCI
  • DalmaneBRNCI
  • LunipaxBRNCI
  • Ro 5-6901CNNCI
DEFINITION
  • The hydrochloride salt form of flurazepam, a member of the benzodiazepines and a long-acting depressor of the central nervous system (CNS) with sedative and hypnotic effects. Flurazepam binds to a specific site on the benzodiazepine-gamma-aminobutyric acid (GABA)-A-chloride ionophore receptor complex located on the neuronal membrane. Binding causes an allosteric modification of the receptor thereby enhancing the affinity of GABA to the receptor leading to an increase in the frequency of chloride-channel opening events, which leads to an increase in chloride ion conductance, neuronal hyperpolarization, inhibition of the action potential, and a decrease in neuronal excitability. By modulating binding of the GABA inhibitory neurotransmitter to GABA-A receptors in the ascending reticular activating system, flurazepam blocks arousal of the cortical and limbic system, thereby exerting its sedative and hypnotic effect.NCI
code
  • C29060
sameAs
http://linked.open...y/mesh/hasConcept
is Has_Salt_Form of
is sameAs of
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