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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Fluocinonide
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
  • Steroid
Preferred_Name
  • Fluocinonide
NSC_Code
  • 101791
UMLS_CUI
  • C0016299
CAS_Registry
  • 356-12-7
Accepted_Therapeutic_Use_For
  • plaque-type psoriasis
FDA_UNII_Code
  • 2W4A77YPAN
Contributing_Source
  • FDA
Chemical_Formula
  • C26H32F2O7
Legacy_Concept_Name
  • Fluocinonide
FULL_SYN
  • FLUOCINONIDEPTFDA2W4A77YPAN
  • FluocinonidePTNCI
  • (6alpha,11beta,16alpha)-21-(Acetyloxy)-6,9-difluoro-11-hydroxy-16,17-[(1-methylethylidene)bis(oxy)]pregna-1,4-diene-3,20-dioneSNNCI
  • LidexBRNCI
  • VanosBRNCI
  • (6alpha,11beta,16alpha)-21-(Acetyloxy)-6,9-difluoro-11-hydroxy-16,17-[(1-methylethylidene)bis(oxy)]pregna-1,4-diene-3,20-dionePTDCP06873
DEFINITION
  • A synthetic glucocorticoid and derivative of fluocinolone acetonide with anti-inflammatory and antipruritic activities. Fluocinonide binds the glucocorticoid receptor, followed by translocation of the ligand-receptor complex to the nucleus and transcription activation of genes containing glucocorticoid-responsive elements. Lipocortin-1 is one factor induced by fluocinonide that interacts and inhibits cytosolic phospholipase 2 alpha, thereby preventing phospholipase translocation to the perinuclear membrane and subsequent release and conversion of arachidonic acid to inflammatory prostaglandins. In addition, MAPK phosphatase 1 is induced, thereby preventing the triggering of the MAPK cascade resulting in pro-inflammatory effects via Jun N-terminal kinase and c-Jun. Finally, fluocinonide binds to and inhibits nuclear factor kappa-B directly, resulting in inhibition of cyclooxygenase 2 transcription and subsequent prostaglandin synthesis.NCI
code
  • C29056
sameAs
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