About: Fenofibrate     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Fenofibrate
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Fenofibrate
UMLS_CUI
  • C0033228
CAS_Registry
  • 49562-28-9
FDA_UNII_Code
  • U202363UOS
Contributing_Source
  • FDA
ALT_DEFINITION
  • A drug used to treat high levels of cholesterol and triglycerides in the blood. Fenofibrate is being studied in the treatment of advanced cancers in young patients and in the treatment of other conditions. It is a type of antilipidemic agent.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 459750
PDQ_Closed_Trial_Search_ID
  • 459750
Chemical_Formula
  • C20H21ClO4
Legacy_Concept_Name
  • Fenofibrate
CHEBI_ID
  • CHEBI:5001
FULL_SYN
  • FenofibratePTNCI
  • fenofibratePTNCI-GLOSSCDR0000518309
  • TriCorPTNCI-GLOSSCDR0000539483
  • TricorBRNCI
  • LofibraPTNCI-GLOSSCDR0000539530
  • FENOFIBRATEPTFDAU202363UOS
DEFINITION
  • A synthetic phenoxy-isobutyric acid derivate and prodrug with antihyperlipidemic activity. Fenofibrate is hydrolyzed in vivo to its active metabolite fenofibric acid that binds to and activates peroxisome proliferator activated receptor alpha (PPARalpha), resulting in the activation of lipoprotein lipase and reduction of the production of apoprotein C-III, an inhibitor of lipoprotein lipase activity. Increased lipolysis and a fall in plasma triglycerides, in turn, leads to the modification of the small, dense low density lipoporotein (LDL) particles into larger particles that are catabolized more rapidly due to a greater affinity for cholesterol receptors. In addition, activation of PPARalpha also increases the synthesis of apoproteins A-I, A-II, and high density lipoprotein (HDL)-cholesterol. Overall, fenofibrate reduces total cholesterol, LDL cholesterol, apolipoprotein B, total triglycerides and triglyceride rich lipoprotein (VLDL) while increasing HDL cholesterol.NCI
code
  • C29047
sameAs
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