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AttributesValues
rdf:type
rdfs:label
  • Tetrandrine
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Tetrandrine
NSC_Code
  • 77037
UMLS_CUI
  • C0076316
CAS_Registry
  • 518-34-3
FDA_UNII_Code
  • 29EX23D5AJ
Contributing_Source
  • FDA
Chemical_Formula
  • C38H42N2O6
Legacy_Concept_Name
  • Tetrandrine
FULL_SYN
  • TetrandrinePTNCI
  • Sinomenine ASYNCI
  • D-tetrandrineSYNCI
  • TetrandrinePTDCP50377
  • Tetrandrine, D-SYNCI
  • Berbaman, 6, 6',7,12-trtramethoxy-2,2'-dimethyl-, (1beta)-(PM)-(9CI)SNNCI
  • (S,S)-TetrandrineSYNCI
  • TETRANDRINEPTFDA29EX23D5AJ
  • (1beta)-6,6',7,12-tetramethoxy-2,2'-dimethylberbamanSNNCI
  • PheanthineSYNCI
  • TetrandrinSYNCI
DEFINITION
  • A natural, bis-benzylisoquinoline alkaloid isolated from the root of the plant Radix stephania tetrandrae. Tetrandrine non-selectively inhibits calcium channel activity and induces G1 blockade of the G1 phase of the cell cycle and apoptosis in various cell types, resulting in immunosuppressive, anti-proliferative and free radical scavenging effects. This agent also increases glucose utilization by enhancing hepatocyte glycogen synthesis, resulting in the lowering of plasma glucose. (NCI04)NCI
code
  • C28952
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