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AttributesValues
rdf:type
rdfs:label
  • Cytochlor
rdfs:subClassOf
Has_Target
Semantic_Type
  • Pharmacologic Substance
  • Nucleic Acid, Nucleoside, or Nucleotide
Preferred_Name
  • Cytochlor
NSC_Code
  • 371331
UMLS_CUI
  • C1328172
In_Clinical_Trial_For
  • Radiosensitizer, squamous cell carcinoma of oral cavity or oropharynx
ALT_DEFINITION
  • A substance being studied in the treatment of cancer. It is a type of radiosensitizer.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 353478
PDQ_Closed_Trial_Search_ID
  • 353478
Legacy_Concept_Name
  • Cytochlor
FULL_SYN
  • CytochlorPTNCI
  • cytochlorPTNCI-GLOSSCDR0000367441
DEFINITION
  • A radio-sensitizing pyrimidine nucleoside with potential antineoplastic activity. Cytochlor is metabolized first to a phosphate derivative, CldCMP, by the enzyme deoxycytidine kinase and then to the active uracyl derivative, CldUMP, by the enzyme dCMP deaminase; deoxycytidine kinase and dCMP deaminase have been found in abnormally high concentrations in most cancers. CldUMP, the active metabolite, incorporates into DNA and, upon exposure to radiation, induces the formation of uracil radicals and double-strand DNA breaks. (NCI04)NCI
code
  • C28950
is someValuesFrom of
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