About: Chlorzoxazone     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Chlorzoxazone
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Chlorzoxazone
NSC_Code
  • 26189
UMLS_CUI
  • C0008296
CAS_Registry
  • 95-25-0
FDA_UNII_Code
  • H0DE420U8G
Contributing_Source
  • FDA
PDQ_Open_Trial_Search_ID
  • 577391
PDQ_Closed_Trial_Search_ID
  • 577391
Chemical_Formula
  • C7H4ClNO2
Legacy_Concept_Name
  • Chlorzoxazone
CHEBI_ID
  • CHEBI:3655
FULL_SYN
  • CHLORZOXAZONEPTFDAH0DE420U8G
  • ChlorzoxazonePTNCI
  • ParaflexBRNCI
DEFINITION
  • A benzoxazolone derivative with mild sedative and centrally-acting muscle relaxant activities. Although its exact mechanism of action is unknown, chlorzoxazone (CZ) appears to act at the spinal cord and subcortical levels of the brain to inhibit multisynaptic reflex arcs involved in producing and maintaining muscle spasms. This agent is extensively hydroxylated by cytochrome P450 2E1 (CYP2E1) to 6-hydroxychlorzoxazone (HCZ),11,12 which is subsequently glucuronidated and eliminated renally. Highly selective for CYP2E1, CZ may be used as a selective probe for phenotyping CYP2E1 in humans; the ratio of HCZ-to-CZ plasma concentrations obtained 2 to 4 hours after oral administration of CZ may be used as a phenotypic measure of CYP2E1 enzymatic activity.NCI
code
  • C28926
sameAs
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