About: Candesartan Cilexetil     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Candesartan Cilexetil
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Candesartan Cilexetil
UMLS_CUI
  • C0527379
CAS_Registry
  • 145040-37-5
FDA_UNII_Code
  • R85M2X0D68
Contributing_Source
  • FDA
PDQ_Open_Trial_Search_ID
  • 546971
PDQ_Closed_Trial_Search_ID
  • 546971
Chemical_Formula
  • C33H34N6O6
Legacy_Concept_Name
  • Candesartan_Cilexetil
FULL_SYN
  • CANDESARTAN CILEXETILPTFDAR85M2X0D68
  • Candesartan CilexetilPTDCP09125
  • AtacandBRNCI
  • BlopressBRNCI
  • Candesartan CilexetilPTNCI
DEFINITION
  • A synthetic, benzimidazole-derived angiotensin II receptor antagonist prodrug with antihypertensive activity. After hydrolysis of candesartan cilexetil to candesartan during gastrointestinal absorption, candesartan selectively competes with angiotensin II for the binding of the angiotensin II receptor subtype 1 (AT1) in vascular smooth muscle, blocking angiotensin II-mediated vasoconstriction and inducing vasodilatation. In addition, antagonism of AT1 in the adrenal gland inhibits angiotensin II-stimulated aldosterone synthesis and secretion by the adrenal cortex; sodium and water excretion increase, followed by a reduction in plasma volume and blood pressure.NCI
code
  • C28903
sameAs
http://linked.open...y/mesh/hasConcept
is sameAs of
Faceted Search & Find service v1.16.118 as of Jun 21 2024


Alternative Linked Data Documents: ODE     Content Formats:   [cxml] [csv]     RDF   [text] [turtle] [ld+json] [rdf+json] [rdf+xml]     ODATA   [atom+xml] [odata+json]     Microdata   [microdata+json] [html]    About   
This material is Open Knowledge   W3C Semantic Web Technology [RDF Data] Valid XHTML + RDFa
OpenLink Virtuoso version 07.20.3240 as of Jun 21 2024, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (126 GB total memory, 48 GB memory in use)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software