About: Bcl-Xs Adenovirus Vaccine     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Bcl-Xs Adenovirus Vaccine
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
  • Immunologic Factor
Preferred_Name
  • Bcl-Xs Adenovirus Vaccine
NSC_Code
  • 689513
UMLS_CUI
  • C1511078
Legacy_Concept_Name
  • Bcl-Xs_Adenovirus_Vaccine
FULL_SYN
  • Bcl-Xs Adenovirus VaccinePTNCI
DEFINITION
  • A vaccine consisting of replication-defective recombinant adenovirus that encodes for Bcl-Xs with potential antineoplastic activity. Vaccination with Bcl-Xs adenovirus vaccine induces apoptosis in Bcl-2 and Bcl-XL positive cancer cells, resulting in decreased tumor growth while leaving normal cells unaffected. Bcl-Xs block the function of the protooncogenes Bcl-2 and Bcl-XL which are overexpressed in a variety of solid tumors and promote cancer cell survival by inhibiting apoptosis. (NCI04)NCI
code
  • C28860
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