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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Aztreonam
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Antibiotic
  • Organic Chemical
Preferred_Name
  • Aztreonam
NSC_Code
  • 646279
UMLS_CUI
  • C0699281
CAS_Registry
  • 78110-38-0
FDA_UNII_Code
  • G2B4VE5GH8
Contributing_Source
  • FDA
Chemical_Formula
  • C13H17N5O8S2
Legacy_Concept_Name
  • Aztreonam
CHEBI_ID
  • CHEBI:161680
FULL_SYN
  • AZTREONAMPTFDAG2B4VE5GH8
  • AzactamBRNCI
  • SQ 26,776CNNCI
  • AztreonamPTNCI
DEFINITION
  • A monocyclic beta-lactam antibiotic originally isolated from Chromobacterium violaceum with bactericidal activity. Aztreonam preferentially binds to and inactivates penicillin-binding protein-3 (PBP-3), which is involved in bacterial cell wall synthesis, thereby inhibiting bacterial cell wall integrity and leading to cell lysis and death. This agent differs from other beta-lactam antibiotics because it is resistant to beta-lactamase hydrolysis, and it is usually used to treat infections caused by gram-negative aerobic microorganisms.NCI
code
  • C28845
sameAs
http://linked.open...y/mesh/hasConcept
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