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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Argatroban
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Argatroban
UMLS_CUI
  • C0048470
CAS_Registry
  • 141396-28-3
FDA_UNII_Code
  • IY90U61Z3S
Contributing_Source
  • FDA
Legacy_Concept_Name
  • Argatroban
CHEBI_ID
  • CHEBI:48720
FULL_SYN
  • MD-805CNNCI
  • ARGATROBANPTFDAIY90U61Z3S
  • 1-[5-guanidino-2-[(3-methyl-1,2,3,4-tetrahydroquinolin-8-yl)sulfonylamino]pentanoyl]-4-methyl-piperidine-2-carboxylic acidSNNCI
  • ArgipidineSYNCI
  • ArgatrobanPTNCI
DEFINITION
  • A synthetic derivative of L-arginine with antithrombotic activity. Argatroban is a univalent and direct inhibitor of fibrin-bound thrombin. This agent reversibly binds to the thrombin active site thereby preventing the thrombin-dependent reactions, which include conversion of fibrinogen to fibrin; the activation of factors V, VIII and XI; the activation of protein C; and platelet aggregation. Argatroban is highly selective for thrombin and is able to inhibit the action of both free and clot-associated thrombin. As a result, stabilization of blood clots and coagulation is inhibited.NCI
code
  • C28833
sameAs
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