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AttributesValues
rdf:type
rdfs:label
  • Acetazolamide
rdfs:subClassOf
Has_Salt_Form
Concept_In_Subset
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Acetazolamide
NSC_Code
  • 145177
UMLS_CUI
  • C0000981
CAS_Registry
  • 59-66-5
FDA_UNII_Code
  • O3FX965V0I
Contributing_Source
  • FDA
Chemical_Formula
  • C4H6N4O3S2
Legacy_Concept_Name
  • Acetazolamide
CHEBI_ID
  • CHEBI:27690
FULL_SYN
  • N-[5-(Aminosulfonyl)-1,3,4-thiadiazol-2-yl]acetamidePTDCP02221
  • ACETAZOLAMIDEPTFDAO3FX965V0I
  • AcetazolamidePTNCI
  • DiacarbFBNCI
  • DiluranFBNCI
  • N-(5-(Aminosulfonyl)-1,3,4-thiadiazol-2-yl)acetamideSNNCI
DEFINITION
  • A sulfonamide derivative with diuretic, antiglaucoma, and anticonvulsant properties. Acetazolamide is a non-competitive inhibitor of carbonic anhydrase, an enzyme found in cells in the proximal tube of the kidney, the eye, and glial cells. Inhibition of this enzyme in the kidney prevents excretion of hydrogen, leading to increased bicarbonate and cation excretion and increased urinary volume, which results in an alkaline diuresis. Acetazolamide reduces the concentration of bicarbonate, resulting in a decreased synthesis of aqueous humor in the eye, thereby lowering intraocular pressure. Although its mechanism of action is unknown, acetazolamide has anti-convulsant properties resulting from indirect effects secondary to metabolic acidosis or direct effects on neuronal transmission. Acetazolamide also produces respiratory stimulant effects in response to changes to both carbon dioxide and oxygen tension levels within the lungs.NCI
code
  • C28809
sameAs
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