About: Replication Initiation

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Attributes	Values
rdf:type	Class
rdfs:label	Replication Initiation
rdfs:subClassOf	Replication-Associated Process
Semantic_Type	Genetic Function
Preferred_Name	Replication Initiation
UMLS_CUI	C1155650
Legacy_Concept_Name	Replication_Initiation
FULL_SYN	Replication InitiationPTNCI DNA Replication InitiationSYNCI
DEFINITION	DNA polymerases are not capable of de novo DNA synthesis and require synthesis of a primer, usually by a DNA-dependent RNA polymerase (primase) to begin DNA synthesis. In eukaryotic cells, the primer is synthesized by DNA polymerase alpha:primase. First, the DNA primase portion of this complex synthesizes approximately 6-10 nucleotides of RNA primer and then the DNA polymerase portion synthesizes an additional 20 nucleotides of DNA. (from MedLine 11395402)NCI
code	C28677
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