About: B-Cell Differentiation

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Attributes	Values
rdf:type	Class
rdfs:label	B-Cell Differentiation
rdfs:subClassOf	Cell Differentiation Process nodeID://b647888 nodeID://b647889 nodeID://b647890 nodeID://b647891
Semantic_Type	Phenomenon or Process
Preferred_Name	B-Cell Differentiation
UMLS_CUI	C1511002
Legacy_Concept_Name	B-Cell_Development
FULL_SYN	B Cell DifferentiationSYNCI B-Cell DifferentiationPTNCI B Lymphocyte DifferentiationSYNCI B-Cell DevelopmentSYNCI
DEFINITION	In mammalian bone marrow, B-Cell Development consists of progressive differentiation from CD34+ progenitor cells to plasma and memory B cells by positive/negative selection in response to local signals, including antigens and cytokines. B cell development begins with immunoglobulin gene somatic recombination and pre-B cell receptor expression. Antigen-induced signal transduction via BCR-associated ITAM molecules activates B cell proliferation. Further differentiation involves additional immunoglobulin gene recombination and expression. Antigen-stimulated circulating (resting) B cells proliferate and differentiate into plasma and memory B cell clones expressing immunoglobulins with the same antigen recognition site.NCI
code	C28391
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