About: Yttrium Y90 (or Indium 111) labeled humanized monoclonal antibody BrE-3     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Yttrium Y90 (or Indium 111) labeled humanized monoclonal antibody BrE-3
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Yttrium Y90 (or Indium 111) labeled humanized monoclonal antibody BrE-3
UMLS_CUI
  • C1520219
Legacy_Concept_Name
  • Yttrium_Y90_or_Indium_111_Labeled_Humanized_Monoclonal_Antibody_BrE-3
FULL_SYN
  • Yttrium Y90 (or Indium 111) labeled humanized monoclonal antibody BrE-3PTNCI
DEFINITION
  • A humanized BrE-3 monoclonal antibody (MoAb) conjugated with either Yttrium Y90 or Indium 111. MoAb BrE-3 is an IgG1-kappa murine monoclonal antibody, which recognizes breast epithelial mucin, a surface antigen expressed by breast cancer cells. This human/mouse chimeric antibody (by joining the murine variable domains to human constant domains) has the same binding affinity and is considerably less immunogenic to humans than the original murine antibody. This MoAb has both imaging and therapeutic uses, when conjugated with either Yttrium Y90 or Indium 111, which emits beta particles and causes cytotoxicity to breast cancer cells.NCI
code
  • C28328
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