About: Topotecan Hydrochloride

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Attributes	Values
rdf:type	Class
rdfs:label	Topotecan Hydrochloride
rdfs:subClassOf	Camptothecin Analogue nodeID://b720081 nodeID://b720082 nodeID://b720083 nodeID://b720084
Has_Free_Acid_Or_Base_Form	TOPOTECAN
Concept_In_Subset	FDA Established Names and Unique Ingredient Identifier Codes Terminology
Semantic_Type	Organic Chemical Pharmacologic Substance
Preferred_Name	Topotecan Hydrochloride
NSC_Code	609699
UMLS_CUI	C0886549
CAS_Registry	119413-54-6
Accepted_Therapeutic_Use_For	Small Cell Lung Carcinoma; Cervical Cancer
In_Clinical_Trial_For	Cervical cancer; malignant glioma; meningeal cancer; myeloid leukemia; neuroblastoma; ovarian epithelial; fallopian tube; or primary peritoneal cancer; prostate cancer; rhabdomyosarcoma; small cell lung cancer; unspecified solid tumors
FDA_UNII_Code	956S425ZCY
Contributing_Source	FDA
ALT_DEFINITION	A drug used to treat certain types of ovarian cancer, lung cancer, and cervical cancer. Hycamtin is a type of topoisomerase inhibitor.NCI-GLOSS
PDQ_Open_Trial_Search_ID	41185
PDQ_Closed_Trial_Search_ID	41185
Chemical_Formula	C23H23N3O5.HCl
Legacy_Concept_Name	Topotecan_Hydrochloride
FULL_SYN	topotecan hydrochloridePTNCI-GLOSSCDR0000507692 Topotecan HydrochloridePTNCI HycamptamineSYNCI SKF S-104864-ACNNCI Topotecan HClSYNCI (S)-10-[(dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7] indolizino[1,2-b] quinoline-3,14-(4H,12H)-dione MonohydrochlorideSNNCI TOPOTECAN HYDROCHLORIDEPTFDA956S425ZCY HycamtinSYDTPNSC0609699 Topotecan hydrochlorideSYDTPNSC0609699 HycamtinPTNCI-GLOSSCDR0000410746 HycamtinBRNCI topotecan hydrochloride (oral)SYNCI
DEFINITION	The hydrochloride salt of a semisynthetic derivative of camptothecin with antineoplastic activity. During the S phase of the cell cycle, topotecan selectively stabilizes topoisomerase I-DNA covalent complexes, inhibiting religation of topoisomerase I-mediated single-strand DNA breaks and producing potentially lethal double-strand DNA breaks when complexes are encountered by the DNA replication machinery. Camptothecin is a cytotoxic quinoline-based alkaloid extracted from the Asian tree Camptotheca acuminata.NCI
code	C2828
sameAs	TOPOTECAN HYDROCHLORIDE TOPOTECAN HYDROCHLORIDE
http://linked.open...y/mesh/hasConcept	http://linked.opendata.cz/resource/mesh/concept/M0329084
is Has_Salt_Form of	TOPOTECAN
is sameAs of	TOPOTECAN HYDROCHLORIDE TOPOTECAN HYDROCHLORIDE TOPOTECAN HYDROCHLORIDE

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