About: Verapamil Hydrochloride     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Verapamil Hydrochloride
rdfs:subClassOf
Has_Free_Acid_Or_Base_Form
Concept_In_Subset
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Verapamil Hydrochloride
NSC_Code
  • 272366
  • 657799
UMLS_CUI
  • C0700468
CAS_Registry
  • 152-11-4
FDA_UNII_Code
  • V3888OEY5R
Contributing_Source
  • FDA
Chemical_Formula
  • C27H38N2O4.ClH
Legacy_Concept_Name
  • Verapamil_Hydrochloride
CHEBI_ID
  • CHEBI:53188
FULL_SYN
  • Verapamil HydrochloridePTNCI
  • (+-)-Verapamil hydrochlorideSYDTPNSC0657799
  • VERAPAMIL HYDROCHLORIDEPTFDAV3888OEY5R
  • CalanBRNCI
  • Verapamil hydrochlorideSYDTPNSC0272366
  • VerelanBRNCI
  • Verapamil HydrochloridePTDCP1090
  • Isoptin SRBRNCI
DEFINITION
  • The hydrochloride form of Verapamil, which is a phenylalkylamine calcium channel blocking agent. Verapamil inhibits the transmembrane influx of extracellular calcium ions into myocardial and vascular smooth muscle cells, causing dilatation of the main coronary and systemic arteries and decreasing myocardial contractility. This agent also inhibits the drug efflux pump P-glycoprotein which is overexpressed in some multi-drug resistant tumors and may improve the efficacy of some antineoplastic agents. (NCI04)NCI
code
  • C2827
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is Has_Salt_Form of
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