About: Radiolabeled CC49     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Radiolabeled CC49
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Radiolabeled CC49
UMLS_CUI
  • C1514701
Legacy_Concept_Name
  • Radiolabeled_CC49
FULL_SYN
  • Radiolabeled CC49PTNCI
DEFINITION
  • A radioimmunoconjugate comprised of a humanized monoclonal antibody with antitumor activity. The monoclonal antibody CC49 is developed from the murine monoclonal antibody B72.3 and is humanized by grafting the hypervariable regions onto the variable light (VL) and variable heavy (VH) frameworks of the monoclonal antibodies LEN and 21/28' CL. The resultant antibody binds the pancarcinoma tumor-associated glycoprotein (TAG)-72 with high affinity. Furthermore, the antibody is commonly radiolabeled resulting in an effective agent for use in radioimmunotherapy for treatment of cancer.NCI
code
  • C2729
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