About: Epothilone D     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Epothilone D
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Epothilone D
NSC_Code
  • 703147
UMLS_CUI
  • C0962559
CAS_Registry
  • 189453-10-9
In_Clinical_Trial_For
  • advanced solid tumors.
FDA_UNII_Code
  • T0358E0YUF
Contributing_Source
  • FDA
ALT_DEFINITION
  • A substance being studied in the treatment of cancer. It is a type of mitotic inhibitor and epothilone.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 38604
PDQ_Closed_Trial_Search_ID
  • 38604
Chemical_Formula
  • C27H41NO5S
Legacy_Concept_Name
  • Epothilone_D
FULL_SYN
  • 12,13-Deoxyepothilone BSYNCI
  • Epothilone DSYDTPNSC0703147
  • (4S-(4R*,7S,8R*,9R*,13Z,16R*(E)))-4,8-Dihydroxy-5,5,7,9,13-pentamethyl-16-(1-methyl-2-(2-methyl-4-thiazolyl)ethenyl)oxacyclohexadec-13-ene-2,6-dioneSNNCI
  • Epothilone DPTNCI
  • epothilone DPTNCI-GLOSSCDR0000367444
  • Epothilone DPTDCP50535
  • KOS-862PTNCI-GLOSSCDR0000367445
  • KOS 862CNNCI
  • Desoxyepothilone BSYNCI
  • EPOTHILONE DPTFDAT0358E0YUF
DEFINITION
  • A natural polyketide compound isolated from the myxobacterium Sorangium cellulosum. Also known as desoxyepothilone B, epothilone D binds to tubulin and inhibits the disassembly of microtubules, resulting in the inhibition of mitosis, cellular proliferation, and cell motility. (NCI04)NCI
code
  • C2672
http://linked.open...y/mesh/hasConcept
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