About: Enzastaurin Hydrochloride     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Enzastaurin Hydrochloride
rdfs:subClassOf
Has_Free_Acid_Or_Base_Form
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Enzastaurin Hydrochloride
UMLS_CUI
  • C1615613
CAS_Registry
  • 359017-79-1
In_Clinical_Trial_For
  • Relapsed or Refractory Lymphoma; High-Grade Gliomas; Solid Tumors.
FDA_UNII_Code
  • KX7K68Z2UH
Contributing_Source
  • FDA
ALT_DEFINITION
  • A substance being studied in the treatment of certain types of cancer, including non-Hodgkin lymphoma, breast, colon, lung, ovarian, and prostate. Enzastaurin hydrochloride blocks certain cell signaling pathways, and may prevent the growth of new blood vessels that tumors need to grow. It is a type of serine threonine kinase inhibitor and a type of antiangiogenesis agent.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 269069
PDQ_Closed_Trial_Search_ID
  • 269069
Chemical_Formula
  • C32H29N5O2.HCl
Legacy_Concept_Name
  • LY317615
FULL_SYN
  • enzastaurin hydrochloridePTNCI-GLOSSCDR0000513020
  • Enzastaurin HydrochloridePTNCI
  • 3-(1-Methyl-1H-indol-3-yl)-4-[1-[1-(2-pyridinylmethyl)-4-piperidinyl]-1H-indol-3-yl]-1H-pyrrole-2,5-dione DihydrochlorideSNNCI
  • LY317615PTNCI-GLOSSCDR0000285925
  • ENZASTAURIN HYDROCHLORIDEPTFDAKX7K68Z2UH
  • LY317615CNNCI
  • 3-(1-Methyl-1H-indol-3-yl)-4-[1-[1-(2-pyridinylmethyl)-4-piperidinyl]-1H-indol-3-yl]-1H-pyrrole-2,5-dione DihydrochloridePTDCP50606
DEFINITION
  • The hydrochloride salt of enzastaurin, a synthetic macrocyclic bisindolemaleimide with potential antineoplastic activity. Binding to the ATP-binding site, enzastaurin selectively inhibits protein kinase C beta, an enzyme involved in the induction of vascular endothelial growth factor (VEGF)-stimulated neo-angiogenesis. This agent may decrease tumor blood supply and so tumor burden.NCI
code
  • C26658
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