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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • R(+)XK469
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • R(+)XK469
NSC_Code
  • 698215
UMLS_CUI
  • C0765292
In_Clinical_Trial_For
  • Advanced Solid Tumors or Lymphoma
ALT_DEFINITION
  • A substance that is being studied in the treatment of leukemia. It belongs to the family of drugs called topoisomerase inhibitors.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 38517
PDQ_Closed_Trial_Search_ID
  • 38517
Legacy_Concept_Name
  • XK469
FULL_SYN
  • Propanoic acid, 2-[4-[(7-chloro-2-quinoxalinyl)oxy]phenoxy}-, (+ )-(R)-SNNCI
  • XK469PTNCI-GLOSSCDR0000045067
  • 2-{4-[(7-chloro-2-quinoxalinyl)oxy]phenoxy}propionic acidSNNCI
  • R(+)XK469PTNCI
DEFINITION
  • The R-isomer of a synthetic quinoxaline phenoxypropionic acid derivative with proapoptotic and antiproliferative activities. R(+)XK469 selectively inhibits topoisomerase II-beta, blocks activation of MEK/MAPK signaling kinases, stimulates caspases, and upregulates p53-dependent proteins, including cyclins A and B1, thereby arresting cancer cells in the G2/M phase of the cell cycle. Both R(+) and S(-) isomers of this agent are cytotoxic, although the R-isomer is more potent. (NCI05)NCI
code
  • C2662
http://linked.open...y/mesh/hasConcept
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